Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23261505 | 0.90 | POLB (0.50) | SIRT6POLBCYP3A4CYP2C19CA1 | |
| SCHEMBL23246160 | 0.81 | SIRT6 (0.67) | SIRT6 | |
| SCHEMBL23261499 | 0.80 | SIRT6 (0.75) | SIRT6CYP3A4CYP2C19IDO1 | |
| SCHEMBL23246166 | 0.77 | SIRT6 (0.44) | SIRT6POLB | |
| SCHEMBL1316516 | 0.76 | HDAC1 (0.45) | SIRT6POLBCYP3A4CYP2C19CA1 | |
| SCHEMBL11358245 | 0.73 | CA1 (0.53) | POLBCYP2C19CA1CA2CA9 | |
| SCHEMBL23246171 | 0.71 | NHERF1 (0.47) | SIRT6POLBCYP3A4 | |
| SCHEMBL31219804 | 0.71 | L3MBTL1 (0.51) | POLBCYP2C19CA1CA2CA9 | |
| SCHEMBL9459478 | 0.71 | NPC1 (0.50) | POLBCYP2C19CA1CA2CA9 | |
| SCHEMBL377108 | 0.70 | HDAC1 (0.45) | POLBCYP3A4CYP2C19CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |