Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23259206 | 0.86 | QDPR (0.47) | GPR119NAMPTPDE4BL3MBTL1LMNA | |
| SCHEMBL23250797 | 0.78 | L3MBTL1 (0.49) | PDE4BL3MBTL1LMNAGAAALDH1A1 | |
| SCHEMBL23259228 | 0.77 | NAMPT (0.46) | NAMPTPDE4BALDH1A1MAPTKDM4E | |
| SCHEMBL8040438 | 0.76 | NAMPT (0.54) | GPR119NAMPTLMNATHRBGAA | |
| SCHEMBL23259175 | 0.75 | KDM1A (0.41) | NAMPTPDE4BBRD4 | |
| SCHEMBL14711416 | 0.74 | GPR119 (0.52) | GPR119NAMPTLMNATHRBGAA | |
| SCHEMBL23259163 | 0.74 | KDM1A (0.39) | NAMPTPDE4B | |
| SCHEMBL8986417 | 0.73 | NAMPT (0.65) | GPR119NAMPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL11437380 | 0.73 | MEN1 (0.50) | PDE4BL3MBTL1LMNAGAAALDH1A1 | |
| SCHEMBL12117456 | 0.73 | GPR119 (0.65) | GPR119NAMPTPDE4BLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |