Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23259226 | 0.86 | GPR119 (0.45) | NAMPTPDE4BDDB1CRBNKDM4E | |
| SCHEMBL23259175 | 0.79 | KDM1A (0.41) | NAMPTPDE4BKDM1A | |
| SCHEMBL23259163 | 0.77 | KDM1A (0.39) | NAMPTPDE4BKDM1A | |
| SCHEMBL23258889 | 0.76 | KDM1A (0.36) | PDE4BTBK1KDM1A | |
| SCHEMBL23259205 | 0.74 | QDPR (0.51) | QDPRNAMPT | |
| SCHEMBL23250759 | 0.74 | QDPR (0.70) | QDPRTLR7KDM4EPRKAB2PRKAG1 | |
| SCHEMBL23258525 | 0.73 | KDM1A (0.42) | PDE4BKDM1A | |
| SCHEMBL4402414 | 0.72 | QDPR (0.59) | QDPRMAPTPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL23258827 | 0.72 | ELANE (0.45) | KDM4EMAPTLMNAALDH1A1KDM1A | |
| SCHEMBL23258874 | 0.72 | ELANE (0.45) | MAPTGPR119LMNAALDH1A1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |