Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23261491 | 0.79 | MAPT (0.39) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL23260709 | 0.78 | MAPT (0.46) | MAPTMEN1KMT2AHTTNPSR1 | |
| SCHEMBL23260794 | 0.78 | MAPT (0.43) | MAPTMEN1KMT2AHTTNPSR1 | |
| SCHEMBL1744862 | 0.69 | ALDH1A1 (0.53) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL13253426 | 0.69 | TDP1 (0.56) | TDP1MAPTHTTNPSR1LMNA | |
| SCHEMBL23842882 | 0.67 | MAPT (0.49) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL7838979 | 0.66 | ALDH1A1 (0.55) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL22636744 | 0.64 | GRIK1 (0.51) | TDP1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23246171 | 0.64 | NHERF1 (0.47) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL23246167 | 0.63 | SIRT6 (0.62) | MAPTMEN1KMT2AHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |