Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 4/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324582 | 0.92 | IKBKB (0.39) | IKBKB | |
| SCHEMBL2327822 | 0.90 | TRPM8 (0.36) | IKBKBNQO2 | |
| SCHEMBL2331129 | 0.85 | RXRA (0.36) | IKBKBHDAC4HDAC1HDAC6 | |
| SCHEMBL2330747 | 0.84 | IKBKB (0.44) | IKBKB | |
| SCHEMBL2332145 | 0.83 | MMP1 (0.38) | MAPK14IKBKB | |
| SCHEMBL2324316 | 0.83 | IKBKB (0.47) | IKBKBHDAC6 | |
| SCHEMBL2332003 | 0.83 | FYN (0.39) | IKBKB | |
| SCHEMBL2329098 | 0.83 | MAPK14 (0.34) | MAPK14IKBKB | |
| SCHEMBL2330683 | 0.83 | ADORA2A (0.38) | IKBKB | |
| SCHEMBL1704482 | 0.80 | MAPK14 (0.34) | MAPK14IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |