Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326516 | 0.74 | ADORA3 (0.45) | PIK3CAMTORLMNA | |
| SCHEMBL11196707 | 0.69 | HTR7 (0.69) | ALDH1A1SMN1; SMN2HPGDMAPK1HTR7 | |
| SCHEMBL737292 | 0.66 | DAO (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HTR7 | |
| SCHEMBL4380182 | 0.66 | KDM4E (0.49) | PIK3CAMTORALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2326904 | 0.66 | ATM (0.61) | PIK3CAMTOR | |
| SCHEMBL2329651 | 0.65 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL202257 | 0.64 | MPO (0.34) | SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7807008 | 0.62 | LMNA (0.76) | HTR7CYP3A4HIF1AP2RX7LMNA | |
| SCHEMBL29971224 | 0.62 | LMNA (0.76) | HTR7CYP3A4HIF1AP2RX7LMNA | |
| SCHEMBL1564239 | 0.61 | GRIN1 (0.55) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356120-A1 | IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010038165-A1 | IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2010-04-08 | — | — | WO | disclosed |