Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13150056 | 0.92 | KCNA5 (0.64) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL29942689 | 0.88 | KDM4E (0.61) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL23301392 | 0.88 | KDM4E (0.61) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL34465709 | 0.86 | LTA4H (0.50) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL15623551 | 0.85 | HRH2 (0.61) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL23301362 | 0.84 | POLB (0.59) | HTTLTA4HALDH1A1HTR7KDM4E | |
| SCHEMBL14375138 | 0.84 | HRH2 (0.61) | HRH2HRH1HTTLTA4HKCNA5 | |
| SCHEMBL1704512 | 0.82 | ALDH1A1 (0.66) | HTTALDH1A1RAB9AGPR183NPC1 | |
| SCHEMBL21405064 | 0.81 | ENPP2 (0.46) | HTTLTA4HDRD3ALDH1A1PKM | |
| SCHEMBL29838280 | 0.81 | ENPP2 (0.46) | HTTLTA4HDRD3ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002367-A1 | BIFUNCTIONAL COMPOUNDS | C4 THERAPEUTICS, INC. | 2023-01-05 | — | — | US | disclosed |
| EP-4054724-A1 | BIFUNCTIONAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2022-09-14 | — | — | EP | disclosed |
| CN-114599428-A | Bifunctional compounds | 豪夫迈·罗氏有限公司 | 2022-06-07 | — | — | CN | disclosed |
| WO-2021086785-A1 | BIFUNCTIONAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002367-A1 | BIFUNCTIONAL COMPOUNDS | ITCH, EGFR, MUC1 | HRH2 1261/4885HRH1 1483/4885HTT 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.