Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.51 |
| ▸ | HPD | P32754 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9336507 | 0.88 | MAPT (0.63) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL410077 | 0.88 | PTGER1 (0.76) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL341109 | 0.85 | SGMS2 (0.62) | MAPTL3MBTL1PTGER1SGMS2MEN1 | |
| SCHEMBL9341625 | 0.84 | L3MBTL1 (0.59) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL16319063 | 0.84 | L3MBTL1 (0.63) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL25720776 | 0.84 | MAPT (0.63) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL6476026 | 0.83 | SGMS2 (0.52) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL28181099 | 0.83 | CHRM4 (0.53) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL28361495 | 0.82 | MAPT (0.57) | MAPTTDP1L3MBTL1MAPK1PTGER1 | |
| SCHEMBL5296788 | 0.80 | KMT2A (0.58) | MAPTL3MBTL1PTGER1SMN1; SMN2SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356103-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | Nycomed GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055083-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-20 | — | — | WO | disclosed |