Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20349882 | 0.81 | RIPK1 (0.43) | ALDH1A1KDM4ESMN1; SMN2RIPK1TSHR | |
| SCHEMBL7591469 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| SCHEMBL13456694 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL23313034 | 0.79 | KDM4E (0.47) | ALDH1A1HSD17B10MAPTGAAKDM4E | |
| SCHEMBL10523005 | 0.79 | ALDH1A1 (0.38) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| SCHEMBL6153221 | 0.78 | RIPK1 (0.51) | ALDH1A1MAPTGAAKDM4EHPGD | |
| SCHEMBL27475694 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| SCHEMBL23425665 | 0.75 | LMNA (0.44) | ALDH1A1HSD17B10MAPTKDM4EPOLB | |
| SCHEMBL10293347 | 0.75 | CTSD (0.53) | ALDH1A1MAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL18387704 | 0.75 | POLB (0.51) | GAAKDM4EPOLBRIPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995061-B2 | SPAK kinase inhibitors as neuroprotective agents | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2021-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995061-B2 | SPAK kinase inhibitors as neuroprotective agents | SBK1, DAPK2, SPAST | ALDH1A1 3598/4885HSD17B10 3693/4885CFTR 4591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.