SCHEMBL12100759

SCHEMBL12100759

Nc1nccc(-c2cccc(-c3ccccc3)c2)c1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP4K4 O95819 4/20 0.46
▸ MAOA P21397 1/20 0.44
▸ MAP3K8 P41279 2/20 0.42
▸ ASIC3 Q9UHC3 1/20 0.42
▸ MAPK1 P28482 1/20 0.41
▸ MAP2K1 Q02750 1/20 0.41
▸ PIK3CA P42336 2/20 0.41
▸ PLAU P00749 1/20 0.40
▸ PIK3CD O00329 1/20 0.38
▸ PIK3CB P42338 1/20 0.38
▸ PIK3CG P48736 1/20 0.38
▸ PRKDC P78527 1/20 0.38
▸ NOS3 P29474 1/20 0.38
▸ NOS2 P35228 1/20 0.38
▸ USP7 Q93009 1/20 0.38
▸ GSK3B P49841 1/20 0.38
▸ SMARCA2 P51531 1/20 0.38
▸ SMARCA4 P51532 1/20 0.38
▸ PBRM1 Q86U86 1/20 0.38
▸ AURKA O14965 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1165179 0.87 GSK3B (0.47) MAP4K4ASIC3MAP2K1PLAUNOS3
SCHEMBL11901043 0.81 MAP4K4 (0.48) MAP4K4MAP2K1PIK3CAPIK3CDPIK3CB
SCHEMBL11902083 0.81 MAP4K4 (0.56) MAP4K4ADORA2A
SCHEMBL17555726 0.81 FYN (0.49) MAP4K4GSK3BPRKACA
SCHEMBL23319557 0.81 MAP4K4 (0.45) MAP4K4NOS3NOS2ADORA2A
SCHEMBL18188070 0.80 MAP4K4 (0.71) MAP4K4MAOAMAP3K8ASIC3MAPK1
SCHEMBL12100694 0.79 MAP4K4 (0.41) MAP4K4MAOAMAP3K8ASIC3MAPK1
SCHEMBL25777691 0.78 MAOA (0.56) MAOAHSP90AA1PRSS1PRSS2PRSS3
SCHEMBL30952878 0.78 MAOA (0.56) MAOAHSP90AA1PRSS1PRSS2PRSS3
SCHEMBL4938505 0.77 DYRK1A (0.54) MAP4K4PIK3CGNOS3NOS2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3936512-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2022-01-12 — — EP disclosed
EP-3424935-B1 IMIDAZOPYRAZINYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORP (US) 2021-08-11 — — EP disclosed
US-10873038-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-12-22 — — US disclosed
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-04-11 — — US disclosed
EP-3424935-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2019-01-09 — — EP disclosed
EP-2683728-B1 IRIDIUM COMPLEXES WITH 3-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE, 3-PHENYL-3H-IMIDAZO[4,5-b]PYRAZINE AND 1-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE CARBENE LIGANDS USED AS PHOSPHORESCENT EMITTERS IN ORGANIC LIGHT EMITTING DEVICES UNIVERSAL DISPLAY CORP (US) 2018-09-05 — — EP disclosed
US-9972793-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-05-15 — — US disclosed
US-20150021590-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-01-22 — — US disclosed
US-8883322-B2 Pyridyl carbene phosphorescent emitters UNIVERSAL DISPLAY CORPORATION (US) 2014-11-11 — — US disclosed
EP-2683728-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2014-01-15 — — EP disclosed
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — US disclosed
WO-2012121936-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10873038-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS PAICS, PIR, NUDC MAP4K4 2758/4885MAOA 3820/4885MAP3K8 2728/4885
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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