Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320410 | 0.90 | NAMPT (0.39) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL23320412 | 0.78 | MEN1 (0.39) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL27157148 | 0.73 | CASP3 (0.43) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL23320451 | 0.72 | NAMPT (0.69) | NAMPT | |
| SCHEMBL23320352 | 0.70 | NAMPT (0.42) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL17112018 | 0.67 | MAPT (0.55) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL23320379 | 0.66 | NAMPT (0.41) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL23320396 | 0.64 | NAMPT (0.36) | NAMPTMAPTPOLBADORA3ADORA1 | |
| SCHEMBL15910787 | 0.62 | MAPT (0.57) | NAMPTMAPTMEN1NPC1LMNA | |
| SCHEMBL28109623 | 0.62 | NPC1 (0.54) | NAMPTMAPTMEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |