Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.41 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320379 | 0.91 | NAMPT (0.41) | NAMPTSLC2A1SLC2A4MKNK1ADORA1 | |
| SCHEMBL23320378 | 0.81 | ADORA3 (0.37) | NAMPTMKNK1ADORA1ADORA3ADORA2A | |
| SCHEMBL23320396 | 0.79 | NAMPT (0.36) | NAMPTQPCTADORA1ADORA3ADORA2A | |
| SCHEMBL24042588 | 0.74 | NAMPT (0.77) | NAMPTROCK2ROCK1RAB9ALMNA | |
| SCHEMBL23320562 | 0.70 | NAMPT (0.40) | NAMPTADORA1ADORA3MEN1KMT2A | |
| SCHEMBL23320420 | 0.70 | ADORA1 (0.54) | ADORA1ADORA3ADORA2ABRAFMAPK14 | |
| SCHEMBL23320566 | 0.70 | NAMPT (0.35) | NAMPTQPCTADORA1ADORA3ADORA2A | |
| SCHEMBL23320369 | 0.70 | QPCT (0.39) | QPCTBRAFRAB9ANPC1LMNA | |
| SCHEMBL23320443 | 0.68 | ADORA1 (0.48) | ADORA1ADORA3ADORA2ABRAFMAPK14 | |
| SCHEMBL30943227 | 0.68 | ADORA1 (0.48) | ADORA1ADORA3ADORA2ABRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |