SCHEMBL23326698

SCHEMBL23326698

O=C(Nc1ccc(O)cc1)c1cc(F)cc(F)c1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 2/20 0.70
SNCA P37840 3/20 0.62
NPC1 O15118 5/20 0.58
RAB9A P51151 5/20 0.58
TOP1 P11387 1/20 0.56
TOP2A P11388 1/20 0.56
TOP2B Q02880 1/20 0.56
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
DEGS1 O15121 2/20 0.54
TP53 P04637 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
PTPN1 P18031 1/20 0.53
MITF O75030 1/20 0.51
POLB P06746 1/20 0.51
TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16677959 0.86 NQO2 (0.84) NQO2SNCANPC1RAB9ATOP1
SCHEMBL5375629 0.84 NPC1 (0.72) NQO2NPC1RAB9AMEN1KMT2A
SCHEMBL677476 0.84 MEN1 (0.67) SNCANPC1RAB9ATOP1TOP2A
SCHEMBL2415708 0.83 PTPN1 (0.76) NQO2SNCANPC1RAB9AMEN1
SCHEMBL4491689 0.83 PTPN1 (0.76) NQO2SNCANPC1RAB9AMEN1
SCHEMBL715515 0.82 NQO2 (1.00) NQO2SNCANPC1RAB9ATOP1
SCHEMBL2915371 0.80 MEN1 (0.81) SNCANPC1RAB9ATOP1TOP2A
SCHEMBL900928 0.80 DEGS1 (0.75) NQO2SNCANPC1RAB9ATOP1
SCHEMBL899585 0.80 DEGS1 (0.75) NQO2SNCANPC1RAB9ATOP1
SCHEMBL8420639 0.80 DEGS1 (0.75) NQO2SNCANPC1RAB9ATOP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4055007-A1 PROSTAGLANDIN ANALOGS AND USES THEREOF Lifex Biolabs, Inc. (US) 2022-09-14 EP disclosed
US-20210139435-A1 PROSTAGLANDIN ANALOGS AND USES THEREOF Lifex Biolabs, Inc. 2021-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210139435-A1 PROSTAGLANDIN ANALOGS AND USES THEREOF PTGDR, NR3C1, PTGIR NQO2 967/4885SNCA 384/4885NPC1 1626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.