SCHEMBL2332848

SCHEMBL2332848

CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCc1cc2ccccc2oc1=O)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 P35372 3/20 0.47
▸ OPRD1 P41143 3/20 0.47
▸ KDR P35968 1/20 0.44
▸ BACE1 P56817 7/20 0.44
▸ NPY4R P50391 7/20 0.44
▸ NPY1R P25929 5/20 0.44
▸ NPY2R P49146 4/20 0.44
▸ NPY5R Q15761 4/20 0.44
▸ BACE2 Q9Y5Z0 2/20 0.44
▸ OPRK1 P41145 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14655975 0.87 KDR (0.41) OPRM1OPRD1KDRBACE1NPY4R
SCHEMBL14968851 0.84 KDR (0.39) OPRM1OPRD1KDRBACE1NPY4R
SCHEMBL4264976 0.84 OPRD1 (0.55) OPRM1OPRD1BACE1BACE2OPRK1
SCHEMBL3366840 0.81 CASP1 (0.51) OPRD1KDRBACE1BACE2
SCHEMBL2157759 0.81 OPRD1 (0.52) OPRM1OPRD1BACE1BACE2OPRK1
SCHEMBL1575643 0.81 NPY4R (0.43) NPY4RNPY1RNPY2RNPY5R
SCHEMBL4321426 0.78 BACE1 (0.44) BACE1BACE2
SCHEMBL73897 0.76 NPY4R (0.60) OPRM1OPRD1BACE1NPY4RNPY1R
SCHEMBL2383875 0.75 MEN1 (0.47) OPRM1OPRD1KDROPRK1
SCHEMBL11038734 0.75 F2RL1 (0.42) KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013014186-A1 METHOD FOR PURIFICATION OF IMMUNOPROTEASOMES ARES TRADING S.A. (CH) 2013-01-31 — — WO disclosed
EP-1372598-B1 USE OF A PHAEODACTYLUM ALGAE EXTRACT TO PROMOTE THE PROTEASOME ACTIVITY OF SKIN CELLS LVMH RECH (FR) 2011-08-17 — — EP disclosed
US-7220417-B2 Use of phaeodactylum algae extract as cosmetic agent promoting the proteasome activity of skin cells and cosmetic composition comprising same LVMH RECHERCHE (FR) 2007-05-22 — — US disclosed
US-20040136945-A1 Use of phaeodactylum algae extract as cosmetic agent promoting the proteasome activity of skin cells and cosmetic composition comprising same LYMH RECHERCHE (FR) 2004-07-15 — — US disclosed
EP-1372598-A2 USE OF A PHAEODACTYLUM ALGAE EXTRACT TO PROMOTE THE PROTEASOME ACTIVITY OF SKIN CELLS LVMH RECHERCHE (FR) 2004-01-02 — — EP disclosed
WO-2002080876-A2 USE OF A PHAEODACTYLUM ALGAE EXTRACT TO PROMOTE THE PROTEASOME ACTIVITY OF SKIN CELLS LVMH RECHERCHE (FR) 2002-10-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040136945-A1 Use of phaeodactylum algae extract as cosmetic agent promoting the proteasome activity of skin cells and cosmetic composition comprising same PSMG3, PSME1, PSMB5 OPRM1 4661/4885OPRD1 4231/4885KDR 4665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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