Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 3/20 | 0.43 |
| ▸ | CCKBR | P32239 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264976 | 0.97 | OPRD1 (0.55) | OPRD1BACE1BACE2OPRM1OPRK1 | |
| SCHEMBL3366840 | 0.89 | CASP1 (0.51) | OPRD1BACE1BACE2 | |
| SCHEMBL2332848 | 0.81 | OPRM1 (0.47) | OPRD1BACE1BACE2OPRM1OPRK1 | |
| SCHEMBL5614017 | 0.81 | MAOB (0.41) | BACE1 | |
| SCHEMBL3370165 | 0.81 | CASP3 (0.46) | — | |
| SCHEMBL4321426 | 0.81 | BACE1 (0.44) | BACE1BACE2 | |
| SCHEMBL6570634 | 0.78 | OPRD1 (0.57) | OPRD1BACE1BACE2OPRM1OPRK1 | |
| SCHEMBL2168561 | 0.78 | CASP3 (0.41) | BACE1BACE2 | |
| SCHEMBL2383875 | 0.77 | MEN1 (0.47) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29408005 | 0.76 | OPRD1 (0.68) | OPRD1BACE1BACE2OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183358-A1 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | THE BURNHAM INSTITUTE (US) | 2011-07-28 | — | — | US | disclosed |