Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264976 | 0.92 | OPRD1 (0.55) | BACE1BACE2OPRD1 | |
| SCHEMBL2157759 | 0.89 | OPRD1 (0.52) | BACE1BACE2OPRD1 | |
| SCHEMBL2168561 | 0.85 | CASP3 (0.41) | CASP1BACE1BACE2CASP3CASP7 | |
| SCHEMBL3370165 | 0.83 | CASP3 (0.46) | CASP1CASP3CASP7 | |
| SCHEMBL2332848 | 0.81 | OPRM1 (0.47) | BACE1BACE2OPRD1KDR | |
| SCHEMBL77937 | 0.80 | OPRD1 (0.51) | CASP1BACE1BACE2OPRD1CASP3 | |
| SCHEMBL5614017 | 0.80 | MAOB (0.41) | BACE1CASP3 | |
| SCHEMBL14655975 | 0.80 | KDR (0.41) | BACE1BACE2OPRD1KDR | |
| SCHEMBL2383875 | 0.79 | MEN1 (0.47) | OPRD1KDR | |
| SCHEMBL9241543 | 0.78 | CASP1 (0.67) | CASP1BACE1BACE2OPRD1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601764-B1 | A CLASS OF METACASPASES | VIB VZW (BE) | 2010-04-28 | — | — | EP | disclosed |
| US-20070271634-A1 | Preventing stress-induced apoptosis in plants | DICKMAN MARTIN B | 2007-11-22 | — | — | US | disclosed |
| US-20060029995-A1 | Novel class of metacaspases | VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW (BE) | 2006-02-09 | — | — | US | disclosed |
| US-6762045-B2 | NUCLEOTIDE SEQUENCES CODING MEMBRANE PROTEIN FOR USE IN THE TREATMENT AUTOIMMUNE DISEASE, CANCER, VIRAL AND BACTERIAL INFECTIONS | IDUN PHARMACEUTICALS, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20020197702-A1 | Membrane derived caspase-3, compositions comprising the same and methods of use therefor | IDUN PHARMACEUTICALS, INC. (US) | 2002-12-26 | — | — | US | disclosed |
| US-20020155579-A1 | Membrane derived caspase-3, compositions comprising the same and methods of use therefor | IDUN PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | US | disclosed |
| US-20020090666-A1 | Methods for detecting membrane derived caspase activity and modulators thereof | IDUN PHARMACEUTICALS, INC. (US) | 2002-07-11 | — | — | US | disclosed |
| US-6391575-B1 | SCREENING FOR ENZYME INHIBITORS BY CONTACTING MEMBRANE FRACTION WITH SUBSTRATE IN PRESENCE AND ABSENCE OF COMPOUND, THEN COMPARING LEVELS OF SUBSTRATE TURNOVER | IDUN PHARMACEUTICALS, INC. | 2002-05-21 | — | — | US | disclosed |
| EP-1161556-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | Idun Pharmaceuticals, Inc. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000052194-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | IDUN PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |