Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP4 | P49662 | 2/20 | 0.50 |
| ▸ | CASP5 | P51878 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23329777 | 0.88 | DRD2 (0.42) | CASP1CASP4CASP5KDM4CHTR6 | |
| SCHEMBL23329405 | 0.79 | KDM4E (0.49) | HRH4PARP1 | |
| SCHEMBL23330166 | 0.74 | NCF1 (0.52) | HRH4 | |
| SCHEMBL23330165 | 0.73 | CKS1B (0.48) | HRH4 | |
| SCHEMBL23329535 | 0.73 | HRH3 (0.41) | HRH4 | |
| SCHEMBL23304489 | 0.71 | HRH4 (0.45) | HTR6HRH4 | |
| SCHEMBL6232666 | 0.70 | USP2 (0.55) | DRD2DRD3 | |
| SCHEMBL1742433 | 0.68 | SCD (0.52) | — | |
| SCHEMBL27793057 | 0.66 | BCL2L1 (0.45) | CASP1CASP4CASP5KDM4C | |
| SCHEMBL23304390 | 0.66 | CHRM3 (0.54) | HTR6HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |