Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP4 | P49662 | 1/20 | 0.38 |
| ▸ | CASP5 | P51878 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23329690 | 0.88 | CASP1 (0.50) | DRD2KDM4CDRD3CASP1CASP4 | |
| SCHEMBL23329405 | 0.77 | KDM4E (0.49) | HRH4 | |
| SCHEMBL23330166 | 0.72 | NCF1 (0.52) | HRH4GBA1 | |
| SCHEMBL23330165 | 0.72 | CKS1B (0.48) | HRH4GBA1 | |
| SCHEMBL23329535 | 0.71 | HRH3 (0.41) | HRH4 | |
| SCHEMBL23304489 | 0.69 | HRH4 (0.45) | CHRM3HTR6HRH4 | |
| SCHEMBL22549339 | 0.67 | HRH4 (0.59) | CHRM3HTR6HRH4 | |
| SCHEMBL28345244 | 0.66 | HRH4 (0.58) | CHRM3HTR6HRH4 | |
| Isophthalic Acid SCHEMBL27810433 | 0.65 | KDM4C (0.51) | DRD2KDM4CDRD3CHRM3 | |
| SCHEMBL19527482 | 0.64 | DRD2 (0.52) | DRD2DRD3CASP1CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |