Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 4/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23304363 | 0.83 | HRH3 (0.41) | HRH3PTPN11OGAWNT1GSK3B | |
| SCHEMBL23330166 | 0.82 | NCF1 (0.52) | HRH3HRH4PTPN11PIK3CA | |
| SCHEMBL23329405 | 0.81 | KDM4E (0.49) | HRH4 | |
| SCHEMBL23330165 | 0.78 | CKS1B (0.48) | HRH3HRH4 | |
| SCHEMBL23304314 | 0.78 | HRH4 (0.45) | HRH3HRH4 | |
| SCHEMBL23329690 | 0.73 | CASP1 (0.50) | HRH4 | |
| SCHEMBL30109094 | 0.71 | HRH3 (0.69) | HRH3OGA | |
| SCHEMBL23329777 | 0.71 | DRD2 (0.42) | HRH4 | |
| SCHEMBL22163216 | 0.70 | HRH3 (0.56) | HRH3PTPN11OGA | |
| SCHEMBL25094874 | 0.69 | PTPN11 (0.40) | HRH3PTPN11F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |