Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23330166 | 0.82 | NCF1 (0.52) | HRH4NCF1 | |
| SCHEMBL23329535 | 0.81 | HRH3 (0.41) | HRH4 | |
| SCHEMBL23684245 | 0.81 | HTR2A (0.46) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL17371701 | 0.79 | ALDH1A1 (0.42) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL1424827 | 0.79 | GBA1 (0.51) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL23330165 | 0.79 | CKS1B (0.48) | HSD17B10HRH4SMN1; SMN2LMNATSHR | |
| SCHEMBL23329690 | 0.79 | CASP1 (0.50) | HRH4PARP1 | |
| SCHEMBL23329777 | 0.77 | DRD2 (0.42) | HRH4 | |
| SCHEMBL23304390 | 0.76 | CHRM3 (0.54) | POLBHRH4ALDH1A1HPGDALOX12 | |
| SCHEMBL30290289 | 0.76 | CHRM3 (0.54) | POLBHRH4ALDH1A1HPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |