SCHEMBL23330854

SCHEMBL23330854

Oc1ncc(N2CCC(F)(F)C2)c(O)n1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 11/20 0.38
F2RL1 P55085 1/20 0.37
CNR1 P21554 2/20 0.34
MAP3K12 Q12852 1/20 0.33
PDE10A Q9Y233 2/20 0.32
SYK P43405 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
SMPD3 Q9NY59 1/20 0.32
DPP4 P27487 1/20 0.32
GSK3A P49840 1/20 0.32
GSK3B P49841 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29597907 0.64 LRRK2 (0.38) CNR2F2RL1MAP3K12
SCHEMBL22023291 0.64 LRRK2 (0.38) CNR2F2RL1MAP3K12
SCHEMBL22236238 0.64 GRIN2D (0.47) PDE10ADPP4
SCHEMBL28590337 0.64 POLB (0.55) CNR2DPP4
SCHEMBL29225192 0.61 HRH3 (0.43) CNR2PDE10A
SCHEMBL30486010 0.61 EP300 (0.43) MAP3K12SYK
SCHEMBL29039125 0.61 EP300 (0.43) MAP3K12SYK
SCHEMBL30667429 0.60 KEAP1 (0.52) CNR2F2RL1PDE10APDE3BPDE3A
SCHEMBL30637430 0.59 SORD (0.47) MAP3K12PDE10ADPP4
SCHEMBL30471929 0.58 CHRNB2 (0.61)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2023-01-26 US disclosed
WO-2021083380-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海科技大学 2021-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF CYP4F11, CYP4A11, HSD11B1 CNR2 3520/4885F2RL1 1854/4885CNR1 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.