Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | UGCG | Q16739 | 2/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912633 | 1.00 | KDM4E (0.47) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL16248689 | 0.94 | KDM4E (0.53) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL26510423 | 0.91 | KDM4E (0.50) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL22912637 | 0.89 | KDM4E (0.47) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL16248683 | 0.89 | KDM4E (0.47) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL19437614 | 0.89 | KDM4E (0.47) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL19437656 | 0.88 | L3MBTL1 (0.47) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL22227353 | 0.86 | KDM4E (0.45) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL22838215 | 0.82 | KDM4E (0.42) | KDM4EPOLBTSHRLTA4HEPHX2 | |
| SCHEMBL18961750 | 0.80 | KDM4E (0.49) | KDM4EPOLBTSHRLTA4HEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395734-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2021-12-23 | — | — | US | disclosed |
| US-20210130823-A1 | COMPOSITIONS AND METHODS | IONIS PHARMACEUTICALS, INC. (US) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130823-A1 | COMPOSITIONS AND METHODS | FUT6, FUT5, GNE | KDM4E 3543/4885POLB 2978/4885TSHR 4110/4885 |
| US-20210395734-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | APOB, APOL1, LDLR | KDM4E 4842/4885POLB 3012/4885TSHR 3750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.