Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | HTR1D | P28221 | 3/20 | 0.33 |
| ▸ | HTR1B | P28222 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823612 | 0.81 | CA2 (0.37) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL16172609 | 0.81 | CXCR2 (0.59) | CXCR2CXCR1DRD2DRD1DRD4 | |
| SCHEMBL1824882 | 0.78 | TDP1 (0.53) | CA2CA12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2424044 | 0.77 | CXCR2 (0.55) | CXCR2CXCR1DRD2DRD1DRD4 | |
| SCHEMBL576035 | 0.76 | CA2 (0.50) | CXCR2CXCR1DRD2DRD1DRD4 | |
| SCHEMBL10194678 | 0.76 | PDE2A (0.50) | HSD11B1ALDH1A1 | |
| SCHEMBL1345636 | 0.75 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL245190 | 0.75 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL1820095 | 0.75 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL13147702 | 0.74 | CXCR2 (0.56) | CXCR2CXCR1DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663960-B1 | AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE SPA (IT) | 2011-08-24 | — | — | EP | disclosed |
| US-7674806-B2 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2010-03-09 | — | — | US | disclosed |
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA.R.MA S.P.A (IT) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | MMP8, CXCL8, MPO | CXCR2 15/4885CXCR1 24/4885DRD2 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.