Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640760 | 0.84 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2336349 | 0.80 | CHRNB2 (0.38) | MEN1KMT2ACYP2D6POLBCYP3A4 | |
| SCHEMBL2629481 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4064598 | 0.77 | USP2 (0.33) | SMN1; SMN2HPGDGPR119 | |
| SCHEMBL641100 | 0.75 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL25258499 | 0.73 | GPR119 (0.50) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2277942 | 0.73 | ALDH1A1 (0.55) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7694218 | 0.72 | GPR119 (0.51) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL186884 | 0.72 | DRD2 (0.59) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29814510 | 0.72 | GPR119 (0.51) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356101-B1 | PYRIMIDINE- AND TRIAZINE-SULFONAMIDE DERIVATIVES AS BRADYKININ B1 RECEPTOR (B1R) INHIBITORS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-2356101-A1 | PYRIMIDINE AND TRIAZINE SULFONAMIDE DERIVATES AS B1 BRADYKININ RECEPTOR (B1R) INHIBITORS FOR TREATING PAIN | Grünenthal GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010046109-A1 | PYRIMIDINE AND TRIAZINE SULFONAMIDE DERIVATES AS B1 BRADYKININ RECEPTOR (B1R) INHIBITORS FOR TREATING PAIN | Grünenthal GmbH (DE) | 2010-04-29 | — | — | WO | disclosed |