Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23339729 | 0.87 | HTR7 (0.48) | HTR1AHTR7HTR2ADRD2DRD4 | |
| SCHEMBL23339699 | 0.79 | DRD4 (0.46) | HTR1AHTR7HTR2AMAPTDRD2 | |
| SCHEMBL23339235 | 0.79 | DRD2 (0.37) | HTR7HTR2AHTR2CALDH1A1DRD2 | |
| SCHEMBL23339232 | 0.75 | ABCB1 (0.47) | — | |
| SCHEMBL4507337 | 0.74 | SIRT6 (0.60) | HTR1AHTR7HTR2AHTR2CSIRT6 | |
| SCHEMBL19926115 | 0.73 | HTR1A (0.58) | HTR1ASIRT6POLBLMNAMAPT | |
| SCHEMBL23339773 | 0.73 | HTR1A (0.43) | HTR1AHTR7HTR2ADRD2DRD3 | |
| SCHEMBL12005663 | 0.72 | SIRT6 (0.63) | HTR1AHTR7SIRT6POLBALDH1A1 | |
| SCHEMBL2730000 | 0.71 | KDM4E (0.63) | HTR1ASIRT6POLBALDH1A1LMNA | |
| SCHEMBL6945690 | 0.71 | SIRT6 (0.65) | HTR1AHTR7SIRT6POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102204-B1 | HIGHLY SELECTIVE SIGMA 1 RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHOPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE UNIV OF MISSISSIPPI (US) | 2021-05-05 | — | — | EP | disclosed |