Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323560 | 0.82 | P4HTM (0.38) | ALDH1A1RAB9ANPC1SMN1; SMN2HDAC3 | |
| SCHEMBL25905785 | 0.80 | ADRA2A (0.40) | ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC8 | |
| SCHEMBL25932371 | 0.80 | P4HTM (0.36) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL12545781 | 0.77 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL16252551 | 0.73 | SMN1; SMN2 (0.54) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL9764596 | 0.72 | ALDH1A1 (0.57) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL24670521 | 0.72 | SMN1; SMN2 (0.52) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL28294216 | 0.71 | P4HTM (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2HDAC3 | |
| SCHEMBL24671110 | 0.70 | SMN1; SMN2 (0.57) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL9350553 | 0.70 | KMT2A (0.68) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739074-B2 | Ras inhibitors | Revolution Medicines, Inc. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| US-20210130326-A1 | RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739074-B2 | Ras inhibitors | KRAS, NRAS, HRAS | ALDH1A1 3951/4885RAB9A 39/4885NPC1 2278/4885 |
| US-20210130326-A1 | RAS INHIBITORS | KRAS, NRAS, HRAS | ALDH1A1 4437/4885RAB9A 37/4885NPC1 2693/4885 |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | KRAS, HRAS, MTOR | ALDH1A1 4528/4885RAB9A 132/4885NPC1 2014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.