Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.39 |
| ▸ | RRM2 | P31350 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25041234 | 0.85 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CP4HTMRRM2 | |
| SCHEMBL23323560 | 0.82 | P4HTM (0.38) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL23342776 | 0.80 | ALDH1A1 (0.46) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL25932371 | 0.80 | P4HTM (0.36) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL30112058 | 0.77 | P4HTM (0.60) | ADRA2AADRA2BADRA2CP4HTMALDH1A1 | |
| SCHEMBL18405340 | 0.77 | P4HTM (0.60) | ADRA2AADRA2BADRA2CP4HTMALDH1A1 | |
| SCHEMBL30112066 | 0.72 | CYP1A2 (0.47) | ADRA2AADRA2BADRA2CP4HTMALDH1A1 | |
| SCHEMBL19555950 | 0.72 | CYP1A2 (0.47) | ADRA2AADRA2BADRA2CP4HTMALDH1A1 | |
| SCHEMBL23325914 | 0.71 | P4HTM (0.36) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL23325913 | 0.71 | HCAR3 (0.61) | ADRA2AADRA2BADRA2CALDH1A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | KRAS, HRAS, MTOR | ADRA2A 4544/4885ADRA2B 4561/4885ADRA2C 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.