Sugi Predict

Sugi Predict / Compounds / SCHEMBL23323560

SCHEMBL23323560

SCHEMBL23323560

CC(C)Nc1ccc(C(=O)N(C)C(C)C)nc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P4HTM Q9NXG6 7/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ HCAR3 P49019 1/20 0.36
▸ HDAC3 O15379 2/20 0.35
▸ HDAC1 Q13547 2/20 0.35
▸ HDAC8 Q9BY41 2/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ HDAC4 P56524 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ CSNK2A1 P68400 1/20 0.35
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HPGD P15428 1/20 0.33
▸ CHRM2 P08172 1/20 0.33
▸ GRM5 P41594 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25932371 0.88 P4HTM (0.36) P4HTMALDH1A1HDAC3HDAC1HDAC8
SCHEMBL23325914 0.82 P4HTM (0.36) P4HTMRXFP1ALDH1A1HCAR3HDAC3
SCHEMBL23342776 0.82 ALDH1A1 (0.46) P4HTMRXFP1ALDH1A1HDAC3HDAC1
SCHEMBL25905785 0.82 ADRA2A (0.40) P4HTMALDH1A1HCAR3HDAC3HDAC1
SCHEMBL25905782 0.76 RXFP1 (0.45) RXFP1ALDH1A1HCAR3HDAC4LMNA
SCHEMBL25884637 0.70 HCAR3 (0.65) HCAR3HDAC4GRM5
SCHEMBL12862942 0.69 ALDH1A1 (0.53) P4HTMALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL19156381 0.69 P4HTM (0.42) P4HTMALDH1A1CSNK2A1NPC1RAB9A
SCHEMBL19766587 0.69 PLA2G1B (0.43) ABL1SMN1; SMN2HPGD
SCHEMBL25884614 0.68 HCAR3 (0.33) ALDH1A1HCAR3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-20230234929-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-20230234929-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-11566007-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2023-01-31 — — US disclosed
US-20210130303-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2021-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11566007-B2 Ras inhibitors KRAS, NRAS, HRAS P4HTM 3119/4885RXFP1 4672/4885ALDH1A1 4437/4885
US-20230234929-A1 RAS INHIBITORS KRAS, NRAS, HRAS P4HTM 3119/4885RXFP1 4672/4885ALDH1A1 4437/4885
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS KRAS, HRAS, MTOR P4HTM 3634/4885RXFP1 4718/4885ALDH1A1 4528/4885
US-20210130303-A1 RAS INHIBITORS KRAS, NRAS, HRAS P4HTM 3119/4885RXFP1 4672/4885ALDH1A1 4437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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