⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925368 | 0.78 | SNCA (0.50) | — | |
| SCHEMBL13382908 | 0.75 | SMYD3 (0.43) | — | |
| SCHEMBL13382919 | 0.75 | MGAT2 (0.40) | — | |
| SCHEMBL24783495 | 0.75 | CYP11B1 (0.47) | — | |
| SCHEMBL20488743 | 0.71 | NOX1 (0.59) | — | |
| SCHEMBL25913327 | 0.71 | NOX1 (0.59) | — | |
| SCHEMBL628205 | 0.69 | TSHR (0.61) | — | |
| SCHEMBL9612794 | 0.69 | APP (0.48) | — | |
| SCHEMBL21511294 | 0.69 | ALDH1A1 (0.60) | — | |
| SCHEMBL14566623 | 0.68 | PDK2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | YALE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20210139436-A1 | Bi-functional Molecules to Degrade Circulating Proteins | YALE UNIVERSITY | 2021-05-13 | — | — | US | disclosed |