Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CEL | P19835 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585017 | 1.00 | HTR3A (0.39) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL1524741 | 1.00 | HTR3A (0.39) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL1524762 | 1.00 | HTR3A (0.39) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL15552104 | 1.00 | HTR3A (0.39) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL6696059 | 0.97 | HTR3A (0.35) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL23611455 | 0.94 | HTR3A (0.34) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL1524893 | 0.91 | HTR3A (0.31) | HTR3AHRH4NOS1NOS2NOS3 | |
| SCHEMBL6693306 | 0.91 | HTR3A (0.40) | HTR3AHRH4DAONOS1NOS2 | |
| SCHEMBL2323788 | 0.91 | HTR3A (0.31) | HTR3AHRH4NOS1NOS2NOS3 | |
| SCHEMBL2463395 | 0.91 | HTR3A (0.31) | HTR3AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139613-B2 | Macrocyclic compounds and methods for their production | NEUROVIVE PHARMACEUTICAL AB (SE) | 2015-09-22 | — | — | US | disclosed |
| EP-2691413-B1 | MACROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION | NEUROVIVE PHARMACEUTICAL AB (SE) | 2014-12-24 | — | — | EP | disclosed |
| US-20140038885-A1 | Macrocyclic Compounds and Methods for Their Production | NEUROVIVE PHARMACEUTICAL AB (SE) | 2014-02-06 | — | — | US | disclosed |
| EP-2691413-A1 | MACROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION | Neurovive Pharmaceutical AB (SE) | 2014-02-05 | — | — | EP | disclosed |
| EP-1948173-B1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012131377-A1 | MACROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION | BIOTICA TECHNOLOGY LIMITED (GB) | 2012-10-04 | — | — | WO | disclosed |
| WO-2011110367-A2 | METHOD OF SCREENING FOR HTRA PROTEASE INHIBITORS USEFUL FOR PROPHYLAXIS AND THERAPY OF A BACTERIAL INFECTION | PAUL-EHRLICH-INSTITUT (DE) | 2011-09-15 | — | — | WO | disclosed |
| WO-2011098805-A1 | SANGLIFEHRIN BASED COMPOUNDS | BIOTICA TECHNOLOGY LIMITED (GB) | 2011-08-18 | — | — | WO | disclosed |
| US-20080312242-A1 | 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2008-12-18 | — | — | US | disclosed |
| US-7427613-B2 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-09-23 | — | — | US | disclosed |
| CN-1283624-C | Prostaglandin derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-11-08 | — | — | CN | disclosed |
| CN-1665782-A | Prostaglandin derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2005-09-07 | — | — | CN | disclosed |
| CN-1144783-C | prostaglandin derivatives | ������ҩ��ʽ���� | 2004-04-07 | — | — | CN | disclosed |
| US-4721523-A | Herbicidal agents containing photosynthesis-inhibiting herbicides in combination with carbamate derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1988-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312242-A1 | 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | REN, AGTR1, ACE | HTR3A 1480/4885HRH4 1605/4885DAO 287/4885 |
| US-20140038885-A1 | Macrocyclic Compounds and Methods for Their Production | HAVCR2, RPL35, CD4 | HTR3A 4175/4885HRH4 2956/4885DAO 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.