Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25801523 | 0.83 | DRD2 (0.46) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL23422372 | 0.79 | ELANE (0.44) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL394985 | 0.79 | DRD2 (0.42) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL1619718 | 0.73 | ASH1L (0.44) | ASH1LSMN1; SMN2ALDH1A1MAPTPIK3CA | |
| SCHEMBL5260809 | 0.72 | ASH1L (0.46) | ASH1LSMN1; SMN2ALDH1A1MAPTPIK3CA | |
| SCHEMBL2843090 | 0.72 | HTR1A (0.42) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL74889 | 0.71 | PDPK1 (0.53) | ASH1LSMN1; SMN2ALDH1A1MAPTPIK3CA | |
| SCHEMBL25273864 | 0.70 | HSD17B10 (0.43) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL30488147 | 0.70 | HSD17B10 (0.43) | DRD2HTR1AHTR2AASH1LSMN1; SMN2 | |
| SCHEMBL289210 | 0.69 | SMN1; SMN2 (0.56) | ASH1LSMN1; SMN2ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534156-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100502-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2011-08-18 | — | — | WO | disclosed |