Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS7 | Q9UKP4 | 11/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 9/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 8/20 | 0.46 |
| ▸ | MMP12 | P39900 | 8/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.46 |
| ▸ | MMP3 | P08254 | 7/20 | 0.46 |
| ▸ | MMP13 | P45452 | 7/20 | 0.46 |
| ▸ | MMP14 | P50281 | 7/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23354695 | 0.92 | ADAMTS7 (0.47) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354017 | 0.90 | ADAMTS7 (0.61) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354182 | 0.90 | ADAMTS7 (0.61) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354087 | 0.87 | ADAMTS7 (0.55) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354306 | 0.87 | ADAMTS7 (0.55) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354816 | 0.86 | ADAMTS7 (0.54) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354784 | 0.84 | ADAMTS7 (0.46) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23384568 | 0.81 | ADAMTS5 (0.46) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL29873864 | 0.81 | ADAMTS5 (0.46) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23354033 | 0.79 | ADAMTS7 (0.47) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058448-B1 | HYDANTOIN DERIVATIVES AS ADAMTS7 ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER AG (DE) | 2024-05-29 | — | — | EP | disclosed |
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-01-26 | — | — | US | disclosed |
| US-20230027985-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-01-26 | — | — | US | disclosed |
| EP-4058448-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2022-09-21 | — | — | EP | disclosed |
| WO-2021094436-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-05-20 | — | — | WO | disclosed |
| WO-2021094434-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-05-20 | — | — | WO | disclosed |
| EP-3822265-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer AG (DE) | 2021-05-19 | — | — | EP | disclosed |
| EP-3822268-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2021-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027985-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | ADAMTS7, MMP7, ADAMTS1 | ADAMTS7 1/4885ADAMTS5 4/4885ADAMTS4 6/4885 |
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | ADAMTS7, MMP7, ADAM17 | ADAMTS7 1/4885ADAMTS5 7/4885ADAMTS4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.