Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337280 | 0.92 | ALDH1A1 (0.36) | LPAR1LPAR2LPAR3KDM4EALDH1A1 | |
| SCHEMBL2338529 | 0.92 | LPAR1 (0.44) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL1286656 | 0.88 | LPAR1 (0.48) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL9998264 | 0.87 | LPAR1 (0.48) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL2341767 | 0.85 | LPAR1 (0.44) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL3702406 | 0.84 | ALDH1A1 (0.36) | LPAR1LPAR2LPAR3KDM4EALDH1A1 | |
| SCHEMBL2636202 | 0.83 | LPAR1 (0.45) | LPAR1KDM4EALDH1A1POLBPKM | |
| SCHEMBL2635999 | 0.82 | ABCC3 (0.39) | LPAR1ABCC4 | |
| SCHEMBL2333488 | 0.82 | HDAC1 (0.43) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL3714448 | 0.82 | LPAR1 (0.41) | LPAR1LPAR2LPAR3ENPP2PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |