Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12717314 | 0.80 | SMN1; SMN2 (0.64) | TAAR1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL7783342 | 0.79 | EPHX1 (0.73) | TAAR1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL8674157 | 0.76 | TAAR1 (0.61) | TAAR1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL14521487 | 0.76 | SMN1; SMN2 (0.68) | TAAR1SMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL28226345 | 0.73 | HPGD (0.72) | TAAR1RAB9ANPC1HPGDPOLB | |
| SCHEMBL26205507 | 0.72 | ALDH1A1 (0.63) | TAAR1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL15695713 | 0.71 | ALDH1A1 (0.67) | RAB9ASMN1; SMN2NPC1HPGDLMNA | |
| SCHEMBL6318345 | 0.71 | ALDH1A1 (0.59) | TAAR1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL28375511 | 0.70 | ALDH1A1 (0.78) | RAB9ASMN1; SMN2NPC1HPGDLMNA | |
| SCHEMBL7070830 | 0.70 | PKM (0.63) | TAAR1RAB9ASMN1; SMN2NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2023-11-21 | — | — | US | disclosed |
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2023-11-21 | — | — | US | disclosed |
| US-20210147395-A1 | NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147395-A1 | NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS | NEK4, NEK2, NEK1 | TAAR1 4544/4885RAB9A 1632/4885SMN1; SMN2 2279/4885 |
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | NEK4, NEK2, NEK1 | TAAR1 4544/4885RAB9A 1632/4885SMN1; SMN2 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.