Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.64 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387283 | 1.00 | SIGMAR1 (0.64) | SIGMAR1TEAD1EPHX2DRD2DRD4 | |
| SCHEMBL29689444 | 0.84 | SIGMAR1 (0.54) | SIGMAR1TEAD1EPHX2USP30MEN1 | |
| SCHEMBL23387369 | 0.83 | SIGMAR1 (0.61) | SIGMAR1TEAD1DRD2DRD4USP30 | |
| SCHEMBL23387367 | 0.83 | SIGMAR1 (0.61) | SIGMAR1TEAD1DRD2DRD4USP30 | |
| SCHEMBL21624785 | 0.82 | USP30 (0.49) | SIGMAR1USP30MEN1KMT2A | |
| SCHEMBL21624784 | 0.82 | USP30 (0.49) | SIGMAR1USP30MEN1KMT2A | |
| SCHEMBL21624752 | 0.80 | MEN1 (0.50) | SIGMAR1EPHX2USP30MEN1KMT2A | |
| SCHEMBL21624753 | 0.80 | MEN1 (0.50) | SIGMAR1EPHX2USP30MEN1KMT2A | |
| SCHEMBL12894863 | 0.80 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD4 | |
| SCHEMBL19254907 | 0.78 | NPC1 (0.65) | SIGMAR1EPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226299-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2022-07-21 | — | — | US | disclosed |
| EP-3950059-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | Nippon Chemiphar Co., Ltd. (JP) | 2022-02-09 | — | — | EP | disclosed |
| EP-3825303-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nippon Chemiphar Co., Ltd. (JP) | 2021-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220226299-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | TRPV3, CACNA1G, TRPV2 | SIGMAR1 1981/4885TEAD1 628/4885EPHX2 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.