Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876920 | 0.84 | POLB (0.67) | NPC1RAB9ASIGMAR1POLBEPHX2 | |
| SCHEMBL9849508 | 0.81 | SMYD3 (0.75) | NPC1RAB9ASIGMAR1POLBEPHX2 | |
| SCHEMBL21624677 | 0.81 | SIGMAR1 (0.55) | NPC1RAB9ASIGMAR1LMNACYP3A4 | |
| SCHEMBL21624674 | 0.81 | SIGMAR1 (0.55) | NPC1RAB9ASIGMAR1LMNACYP3A4 | |
| SCHEMBL19255256 | 0.80 | KMT2A (0.64) | MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL9849509 | 0.80 | SMYD3 (0.77) | SIGMAR1POLBEPHX2MEN1KMT2A | |
| SCHEMBL9325905 | 0.79 | NPC1 (1.00) | NPC1RAB9ASIGMAR1POLBEPHX2 | |
| SCHEMBL5053663 | 0.79 | RAB9A (0.71) | NPC1RAB9APOLBEPHX2MEN1 | |
| SCHEMBL7652620 | 0.79 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL19254905 | 0.79 | SMN1; SMN2 (0.72) | NPC1RAB9ASIGMAR1POLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247976-B2 | Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2022-02-15 | — | — | US | disclosed |
| US-10322112-B2 | Compound combinations for attenuation of bacterial virulence | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2019-06-18 | — | — | US | disclosed |
| US-20190144407-A1 | Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-05-16 | — | — | US | disclosed |
| US-20170231962-A1 | Compound Combinations for Attenuation of Bacterial Virulence | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231962-A1 | Compound Combinations for Attenuation of Bacterial Virulence | PNISR, PGLS, QRFPR | NPC1 4739/4885RAB9A 127/4885SIGMAR1 664/4885 |
| US-20190144407-A1 | Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor | AREG, QRFPR, GPR139 | NPC1 4867/4885RAB9A 2846/4885SIGMAR1 353/4885 |
| US-10322112-B2 | Compound combinations for attenuation of bacterial virulence | PNISR, BLVRB, PGLS | NPC1 4653/4885RAB9A 286/4885SIGMAR1 225/4885 |
| US-11247976-B2 | Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor | AREG, QRFPR, GPR139 | NPC1 4867/4885RAB9A 2846/4885SIGMAR1 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.