Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | GRK2 | P25098 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 2/20 | 0.43 |
| ▸ | ME1 | P48163 | 2/20 | 0.43 |
| ▸ | ME3 | Q16798 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424646 | 0.87 | KDM4E (0.63) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL1065084 | 0.82 | ITGB3 (0.64) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL2285282 | 0.82 | ITGB3 (0.64) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL2371447 | 0.81 | ITGB3 (0.63) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL2282564 | 0.81 | ITGB3 (0.62) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL13855699 | 0.81 | ITGB3 (0.62) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL2649726 | 0.79 | ITGB3 (0.60) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| Hydrochloric Acid SCHEMBL9679970 | 0.79 | ITGB3 (0.60) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL24059106 | 0.78 | ITGB3 (0.58) | ITGB3ITGA2BPOLBNSD2GRK2 | |
| SCHEMBL4541029 | 0.78 | ITGB3 (0.59) | ITGB3ITGA2BPOLBNSD2GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226299-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2022-07-21 | — | — | US | disclosed |
| EP-3950059-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | Nippon Chemiphar Co., Ltd. (JP) | 2022-02-09 | — | — | EP | disclosed |
| EP-3825303-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nippon Chemiphar Co., Ltd. (JP) | 2021-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220226299-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | TRPV3, CACNA1G, TRPV2 | ITGB3 1361/4885ITGA2B 2489/4885POLB 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.