Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 8/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339656 | 0.86 | MEN1 (0.44) | MEN1RAB9AKMT2AKDM4ENPC1 | |
| SCHEMBL2267949 | 0.78 | CSNK2A1 (0.41) | MEN1RAB9AKMT2AKDM4EIDO1 | |
| Iodide SCHEMBL11590383 | 0.77 | CSNK2A1 (0.40) | MEN1RAB9AKMT2AKDM4EIDO1 | |
| Bromide SCHEMBL11357233 | 0.77 | CSNK2A1 (0.40) | MEN1RAB9AKMT2AKDM4EIDO1 | |
| Hydrochloric Acid SCHEMBL11589235 | 0.77 | ALDH1A1 (0.42) | MEN1RAB9AKMT2AKDM4EIDO1 | |
| SCHEMBL17348545 | 0.74 | BCL2 (0.44) | MEN1RAB9AKMT2AKDM4ENPC1 | |
| SCHEMBL4612059 | 0.72 | SLC6A2 (0.43) | MEN1RAB9AKMT2ABCL2MCL1 | |
| SCHEMBL14838063 | 0.72 | IDO1 (0.43) | MEN1RAB9AKMT2AKDM4EHSP90AA1 | |
| SCHEMBL3673663 | 0.70 | PARP1 (0.40) | MEN1RAB9AKMT2AKDM4EERN1 | |
| SCHEMBL2273204 | 0.68 | ABL1 (0.47) | MEN1RAB9AKMT2ANPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102292083-A | Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives | — | 2011-12-21 | — | — | CN | disclosed |
| CN-102292083-A | Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives | — | 2011-12-21 | — | — | CN | disclosed |
| US-20110301146-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-12-08 | — | — | US | disclosed |
| US-20110301146-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-12-08 | — | — | US | disclosed |
| CN-102271514-A | 7-Hydroxy-benzoimidazole-4-yl-methanone derivatives and PBK inhibitors containing the Same | — | 2011-12-07 | — | — | CN | disclosed |
| CN-102271514-A | 7-Hydroxy-benzoimidazole-4-yl-methanone derivatives and PBK inhibitors containing the Same | — | 2011-12-07 | — | — | CN | disclosed |
| US-20110263566-A1 | 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK Inhibitors Containing the Same | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263566-A1 | 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK Inhibitors Containing the Same | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263566-A1 | 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK Inhibitors Containing the Same | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-27 | — | — | US | disclosed |
| EP-2364087-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | Oncotherapy Science, Inc. (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2364087-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | Oncotherapy Science, Inc. (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2358365-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | Oncotherapy Science, Inc. (JP) | 2011-08-24 | — | — | EP | disclosed |
| EP-2358365-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | Oncotherapy Science, Inc. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010058512-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010058512-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263566-A1 | 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK Inhibitors Containing the Same | PDXK, BCKDK, SBK1 | MEN1 2904/4885RAB9A 4165/4885KMT2A 1937/4885 |
| US-20110301146-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | GSK3B, GSK3A, GYS2 | MEN1 2637/4885RAB9A 4158/4885KMT2A 2496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.