SCHEMBL23405489

SCHEMBL23405489

Oc1ccc(-c2cn(-c3ccc(F)cc3)nn2)cc1O

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.78
▸ SNCA P37840 1/20 0.78
▸ FLT3 P36888 2/20 0.63
▸ PTGS2 P35354 5/20 0.59
▸ CA1 P00915 4/20 0.59
▸ CA2 P00918 4/20 0.59
▸ CA5A P35218 4/20 0.59
▸ CA5B Q9Y2D0 4/20 0.59
▸ PTGS1 P23219 1/20 0.56
▸ HSD17B1 P14061 2/20 0.54
▸ HSD17B2 P37059 2/20 0.54
▸ CA12 O43570 2/20 0.47
▸ CA9 Q16790 2/20 0.47
▸ HDAC3 O15379 1/20 0.47
▸ HDAC1 Q13547 1/20 0.47
▸ HDAC2 Q92769 1/20 0.47
▸ HDAC10 Q969S8 1/20 0.47
▸ HDAC8 Q9BY41 1/20 0.47
▸ HDAC6 Q9UBN7 1/20 0.47
▸ STS P08842 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23405495 0.88 MAPT (0.82) MAPTSNCAFLT3PTGS2CA1
SCHEMBL12682333 0.88 SNCA (1.00) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23405494 0.87 MAPT (0.81) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23405482 0.86 MAPT (0.83) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23405479 0.86 MAPT (0.78) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23405496 0.85 MAPT (0.78) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23430997 0.85 MAPT (0.77) MAPTSNCAPTGS2CA1CA2
SCHEMBL23405505 0.85 MAPT (0.72) MAPTSNCAFLT3PTGS2CA1
SCHEMBL16220811 0.84 PTGS2 (0.72) MAPTSNCAFLT3PTGS2CA1
SCHEMBL23557718 0.83 PTGS2 (0.63) MAPTSNCAFLT3PTGS2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297178-B2 Triazole derivative and use thereof GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2025-05-13 — — US claimed
US-20240166611-A1 TRIAZOLE DERIVATIVE AND USE THEREOF GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2024-05-23 — — US claimed
US-20210163425-A1 TRIAZOLE DERIVATIVE AND USE THEREOF GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2021-06-03 — — US claimed
US-12297178-B2 Triazole derivative and use thereof GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2025-05-13 — — US disclosed
US-20240166611-A1 TRIAZOLE DERIVATIVE AND USE THEREOF GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2024-05-23 — — US disclosed
US-20210163425-A1 TRIAZOLE DERIVATIVE AND USE THEREOF GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2021-06-03 — — US disclosed
US-20210163425-A1 TRIAZOLE DERIVATIVE AND USE THEREOF GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2021-06-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163425-A1 TRIAZOLE DERIVATIVE AND USE THEREOF FABP4, LIPC, GPR119 MAPT 2951/4885SNCA 4775/4885FLT3 386/4885
US-12297178-B2 Triazole derivative and use thereof FABP4, LIPC, GPR119 MAPT 2945/4885SNCA 4771/4885FLT3 430/4885
US-20240166611-A1 TRIAZOLE DERIVATIVE AND USE THEREOF FABP4, LIPC, GPR119 MAPT 2945/4885SNCA 4771/4885FLT3 430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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