SCHEMBL23408581 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	IRAK4	Q9NWZ3	2/20	0.39

▸	NTRK1	P04629	16/20	0.39

▸	STAT6	P42226	1/20	0.34

▸	NTRK3	Q16288	2/20	0.33

▸	NTRK2	Q16620	2/20	0.33

▸	JAK2	O60674	1/20	0.33

▸	ABL1	P00519	1/20	0.33

▸	INSR	P06213	1/20	0.33

▸	LCK	P06239	1/20	0.33

▸	CSF1R	P07333	1/20	0.33

▸	LYN	P07948	1/20	0.33

▸	RET	P07949	1/20	0.33

▸	IGF1R	P08069	1/20	0.33

▸	MET	P08581	1/20	0.33

▸	ROS1	P08922	1/20	0.33

▸	PDGFRB	P09619	1/20	0.33

▸	FGR	P09769	1/20	0.33

▸	KIT	P10721	1/20	0.33

▸	SRC	P12931	1/20	0.33

▸	BRAF	P15056	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23408737	0.84	NTRK1 (0.40)	IRAK4NTRK1ABL1
SCHEMBL23408580	0.81	NTRK1 (0.54)	NTRK1
SCHEMBL23408813	0.81	NTRK1 (0.45)	IRAK4NTRK1ABL1
SCHEMBL22084288	0.76	NTRK1 (0.46)	IRAK4NTRK1
SCHEMBL23408626	0.76	IRAK4 (0.38)	IRAK4NTRK1NTRK3NTRK2JAK2
SCHEMBL22084290	0.75	NTRK1 (0.44)	IRAK4NTRK1
SCHEMBL22084170	0.72	NTRK1 (0.45)	IRAK4NTRK1ABL1
SCHEMBL22083695	0.71	NTRK1 (0.41)	IRAK4NTRK1
SCHEMBL23408576	0.70	PIM1 (0.40)	IRAK4NTRK1NTRK3NTRK2
SCHEMBL23408640	0.69	PIM1 (0.40)	IRAK4NTRK1NTRK3NTRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021098745-A1	PREPARATION AND APPLICATION OF A CLASS OF PROTEIN RECEPTOR KINASE INHIBITORS	上海轶诺药业有限公司	2021-05-27	—	—	WO	disclosed