Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13052122 | 0.85 | ACHE (0.66) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5068516 | 0.84 | HDAC8 (0.65) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5067508 | 0.84 | LOXL2 (0.61) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5776546 | 0.83 | CYP4A11 (0.57) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL24835147 | 0.83 | CYP4A11 (0.57) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL8781971 | 0.82 | LOXL2 (0.59) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL23374683 | 0.82 | LOXL2 (0.51) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5775042 | 0.82 | LOXL2 (0.56) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL846524 | 0.82 | SIGMAR1 (0.51) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL9639788 | 0.82 | LOXL2 (0.47) | LOXL2ALDH1A1KDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021101919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-05-27 | — | — | WO | disclosed |