SCHEMBL23440345

SCHEMBL23440345

CCCC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc(OC)cc1)C2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSB P07858 1/20 0.51
CTSS P25774 1/20 0.51
CTSK P43235 1/20 0.51
CYP3A4 P08684 13/20 0.49
USP2 O75604 9/20 0.49
CYP2C9 P11712 8/20 0.49
ALDH1A1 P00352 8/20 0.49
CYP2C19 P33261 6/20 0.49
MAPK1 P28482 5/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
HIF1A Q16665 6/20 0.48
CYP1A2 P05177 6/20 0.48
HSD17B10 Q99714 5/20 0.48
CYP2D6 P10635 4/20 0.48
TSHR P16473 4/20 0.48
SMN1; SMN2 Q16637 5/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23439554 0.89 CYP3A4 (0.48) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL23439900 0.88 CYP3A4 (0.56) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL23411518 0.87 CYP3A4 (0.55) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL23439605 0.81 DRD2 (0.56) CYP3A4USP2ALDH1A1CYP2C19MEN1
SCHEMBL485392 0.80 CYP11B2 (0.54) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL4072450 0.78 CYP3A4 (0.63) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL29933185 0.75 CYP3A4 (0.53) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL23411493 0.75 CYP3A4 (0.53) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL31683385 0.75 CYP11B2 (0.51) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL29933261 0.75 GPR119 (0.62) CYP3A4USP2CYP2C9ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021105116-A1 SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2021-06-03 WO disclosed