SCHEMBL23441503

SCHEMBL23441503

COc1ccc(-c2cnnc(OC[C@H]3CC[C@H](C(F)(F)F)CC3)c2)cc1[C@@H]1C[C@H]1C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LTC4S Q16873 6/20 0.36
FFAR1 O14842 3/20 0.36
TRPC6 Q9Y210 1/20 0.36
FFAR4 Q5NUL3 5/20 0.35
SCN9A Q15858 2/20 0.35
HTR2C P28335 2/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23441518 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL23441541 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL31305496 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL30406011 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL23441505 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL23441519 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL23441517 1.00 LTC4S (0.36) LTC4SFFAR1TRPC6FFAR4SCN9A
SCHEMBL29318117 0.90 HTR2C (0.37) LTC4SFFAR1FFAR4HTR2CCYP11B1
SCHEMBL29318119 0.90 HTR2C (0.37) LTC4SFFAR1FFAR4HTR2CCYP11B1
SCHEMBL27194558 0.87 KDM1A (0.36) LTC4STRPC6FFAR4SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219452-B1 NOVEL 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORP (JP) 2025-01-01 EP claimed
US-20240239756-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-07-18 US claimed
US-11958812-B2 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-04-16 US claimed
EP-4219452-A1 NOVEL 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME Mitsubishi Tanabe Pharma Corporation (JP) 2023-08-02 EP claimed
EP-3831812-B1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORP (JP) 2023-05-10 EP claimed
US-20220298118-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2022-09-22 US claimed
EP-3831812-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME Mitsubishi Tanabe Pharma Corporation (JP) 2021-06-09 EP claimed
CN-112469699-A Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and medical application thereof 田边三菱制药株式会社 2021-03-09 CN claimed
US-12404247-B2 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-09-02 US disclosed
EP-4527464-A2 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME Mitsubishi Tanabe Pharma Corporation (JP) 2025-03-26 EP disclosed
EP-4219452-B1 NOVEL 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORP (JP) 2025-01-01 EP disclosed
US-20240239756-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-07-18 US disclosed
US-20240239756-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-07-18 US disclosed
US-11958812-B2 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same MITSUBISHI TANABE PHARMA CORPORATION (JP) 2024-04-16 US disclosed
CN-112469699-B Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and medical application thereof 田边三菱制药株式会社 2024-02-23 CN disclosed
EP-4219452-A1 NOVEL 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME Mitsubishi Tanabe Pharma Corporation (JP) 2023-08-02 EP disclosed
EP-3831812-B1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORP (JP) 2023-05-10 EP disclosed
US-20220298118-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2022-09-22 US disclosed
EP-3831812-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME Mitsubishi Tanabe Pharma Corporation (JP) 2021-06-09 EP disclosed
CN-112469699-A Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and medical application thereof 田边三菱制药株式会社 2021-03-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404247-B2 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same ENPP2, PGA5, PLPBP LTC4S 309/4885FFAR1 1889/4885TRPC6 828/4885
US-20220298118-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME ATXN2, ATXN10, ATXN2L LTC4S 579/4885FFAR1 3355/4885TRPC6 2317/4885
US-20240239756-A1 NOVEL 3, 5-DISUBSTITUTED PYRIDINE AND 3, 5-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL USE OF SAME ENPP2, SSB, PLPBP LTC4S 218/4885FFAR1 1458/4885TRPC6 537/4885
US-11958812-B2 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same ATXN2, ATXN10, ARSA LTC4S 442/4885FFAR1 3341/4885TRPC6 2794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.