Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16125657 | 0.91 | ALDH1A1 (0.42) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL11189746 | 0.86 | METAP2 (0.46) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL22751568 | 0.86 | METAP2 (0.46) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL906813 | 0.85 | — | — | |
| SCHEMBL24950429 | 0.84 | TSHR (0.49) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL11271140 | 0.84 | TSHR (0.49) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL9495243 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHTTGAAMGAM | |
| SCHEMBL27906395 | 0.83 | — | — | |
| SCHEMBL11546997 | 0.83 | — | — | |
| SCHEMBL26789029 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHTTGAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-04-17 | — | — | US | disclosed |
| US-12195478-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-01-14 | — | — | US | disclosed |
| EP-4487913-A2 | OPIOID RECEPTOR MODULATORS | The Trustees Of Columbia University In The City Of New York (US) | 2025-01-08 | — | — | EP | disclosed |
| EP-3224261-B1 | OPIOID RECEPTOR MODULATORS | UNIV COLUMBIA (US) | 2024-09-18 | — | — | EP | disclosed |
| US-11840541-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-31 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
| EP-3224261-A1 | OPIOID RECEPTOR MODULATORS | The Trustees of Columbia University in the City of New York (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-2078724-B1 | PROCESS FOR PRODUCTION OF DIALKYLTIN DIALKOXIDES | ASAHI CHEMICAL IND (JP) | 2016-11-30 | — | — | EP | disclosed |
| WO-2016086158-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-06-02 | — | — | WO | disclosed |
| US-8008518-B2 | Process for producing dialkyl tin dialkoxides | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2011-08-30 | — | — | US | disclosed |
| US-20100041908-A1 | PROCESS FOR PRODUCING DIALKYL TIN DIALKOXIDES | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2010-02-18 | — | — | US | disclosed |
| EP-2078724-A1 | PROCESS FOR PRODUCTION OF DIALKYLTIN DIALKOXIDES | Asahi Kasei Chemicals Corporation (JP) | 2009-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041908-A1 | PROCESS FOR PRODUCING DIALKYL TIN DIALKOXIDES | DEK, DDT, DERA | SMN1; SMN2 4349/4885LMNA 4325/4885HTT 1178/4885 |
| US-12195478-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | SMN1; SMN2 3917/4885LMNA 3314/4885HTT 892/4885 |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | SMN1; SMN2 4640/4885LMNA 3638/4885HTT 1353/4885 |
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | SMN1; SMN2 3917/4885LMNA 3314/4885HTT 892/4885 |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | SMN1; SMN2 3917/4885LMNA 3314/4885HTT 892/4885 |
| US-11840541-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | SMN1; SMN2 4640/4885LMNA 3638/4885HTT 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.