Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23449322 | 0.77 | CD44 (0.33) | HDAC4KDM1ACYP1A2CYP2A6TSHR | |
| SCHEMBL23446684 | 0.77 | CYP1A2 (0.44) | RECQLTAAR1PDK2HDAC4KDM1A | |
| SCHEMBL29740745 | 0.75 | TP53 (0.39) | RECQLPDK2CYP1A2LMNATP53 | |
| SCHEMBL4455636 | 0.75 | TP53 (0.39) | RECQLPDK2CYP1A2LMNATP53 | |
| SCHEMBL23406085 | 0.75 | PDE7A (0.30) | PDE7A | |
| SCHEMBL23406084 | 0.75 | HTR2A (0.31) | HTR2AHTR2CHTR2BALDH1A1PDE7A | |
| SCHEMBL23448749 | 0.75 | PDK2 (0.34) | PDK2HDAC4BACE1HTR2AHTR2C | |
| SCHEMBL23450028 | 0.72 | CA2 (0.32) | PDK2 | |
| SCHEMBL23448752 | 0.72 | PDE7A (0.33) | PDK2PDE7A | |
| SCHEMBL8015643 | 0.72 | CYP3A4 (0.38) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2022-12-20 | — | — | US | disclosed |
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | TALDO1, REN, PKD1 | RECQL 1524/4885TAAR1 89/4885PDK2 852/4885 |
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ORMDL3, TALDO1, TAC3 | RECQL 1723/4885TAAR1 77/4885PDK2 320/4885 |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ORMDL3, TALDO1, TAC3 | RECQL 1738/4885TAAR1 76/4885PDK2 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.