Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740745 | 1.00 | TP53 (0.39) | TP53CYP1A2ACHEALDH1A1LMNA | |
| SCHEMBL11161161 | 0.85 | ACHE (0.41) | TP53CYP1A2ACHEALDH1A1LMNA | |
| SCHEMBL4465971 | 0.83 | TP53 (0.35) | TP53CYP1A2ACHEALDH1A1LMNA | |
| SCHEMBL9843567 | 0.79 | TP53 (0.40) | TP53CYP1A2ACHEALDH1A1LMNA | |
| SCHEMBL9326775 | 0.78 | CYP1A2 (0.46) | TP53CYP1A2ALDH1A1LMNAHPGD | |
| SCHEMBL23449322 | 0.77 | CD44 (0.33) | CYP1A2ACHEALDH1A1OPRD1CA2 | |
| SCHEMBL29404169 | 0.76 | CYP1A2 (0.49) | TP53CYP1A2ACHEALDH1A1HPGD | |
| SCHEMBL21565109 | 0.76 | ACHE (0.38) | TP53CYP1A2ACHEALDH1A1RECQL | |
| SCHEMBL4458909 | 0.76 | CYP1A2 (0.49) | TP53CYP1A2ACHEALDH1A1HPGD | |
| SCHEMBL11156773 | 0.76 | MEN1 (0.40) | TP53CYP1A2ACHEALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291497-B2 | 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol | ZHEJIANG UNIVERSITY (CN) | 2025-05-06 | — | — | US | claimed |
| US-20220213015-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | claimed |
| US-12291497-B2 | 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol | ZHEJIANG UNIVERSITY (CN) | 2025-05-06 | — | — | US | disclosed |
| US-12291497-B2 | 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol | ZHEJIANG UNIVERSITY (CN) | 2025-05-06 | — | — | US | disclosed |
| US-12291497-B2 | 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol | ZHEJIANG UNIVERSITY (CN) | 2025-05-06 | — | — | US | disclosed |
| EP-4130152-A1 | GLASS-FIBER-CONTAINING FLAME-RETARDANT POLYCARBONATE RESIN COMPOSITION AND MOLDED OBJECT | ADEKA CORPORATION (JP) | 2023-02-08 | — | — | EP | disclosed |
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2022-12-20 | — | — | US | disclosed |
| US-20220213015-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-20220213015-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-20220213015-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-11377457-B2 | 3,3,3',3'-tetramethyl-1,1'-spirobiindane-based monophosphine ligand, intermediates thereof, preparation method and use of the same | ZHEJIANG UNIVERSITY (CN) | 2022-07-05 | — | — | US | disclosed |
| EP-0694582-A2 | A glass-fiber-reinforced polycarbonate resin composition | GENERAL ELECTRIC COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0694581-A2 | A polycarbonate resin composition | GENERAL ELECTRIC COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5418269-A | Made by ester interchange, mold release, thermal stability, little discoloration on molding, disks | GE PLASTICS JAPAN (JP) | 1995-05-23 | — | — | US | disclosed |
| US-5403878-A | With alpha olefin oligomer and acidic sulfur compound; mold releasing, thermostability | CITIBANK, N.A., AS COLLATERAL AGENT | 1995-04-04 | — | — | US | disclosed |
| US-5389713-A | Polycarbonate formed by melt polymerization of aromatic dihydroxy compound and carbonate diester, alpha-olefin oligomer, acidic sulfur-containing compound | GE PLASTICS JAPAN (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0605157-A2 | Resin compositions | GE PLASTICS JAPAN LIMITED (JP) | 1994-07-06 | — | — | EP | disclosed |
| EP-0561638-A1 | Optical-grade polycarbonate resin compositions | GE PLASTICS JAPAN LIMITED (JP) | 1993-09-22 | — | — | EP | disclosed |
| EP-0561629-A2 | Polycarbonate resin compositions | GE PLASTICS JAPAN LIMITED (JP) | 1993-09-22 | — | — | EP | disclosed |
| EP-0561630-A2 | Polycarbonate resin compositions for optical use | GE PLASTICS JAPAN LIMITED (JP) | 1993-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213015-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL | BPGM, BRSK2, TALDO1 | TP53 4718/4885CYP1A2 1139/4885ACHE 2862/4885 |
| US-11377457-B2 | 3,3,3',3'-tetramethyl-1,1'-spirobiindane-based monophosphine ligand, intermediates thereof, preparation method and use of the same | PHOSPHO1, TPI1, TPR | TP53 4731/4885CYP1A2 833/4885ACHE 1424/4885 |
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ORMDL3, TALDO1, TAC3 | TP53 4784/4885CYP1A2 1246/4885ACHE 1789/4885 |
| US-12291497-B2 | 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol | BPGM, PHOSPHO1, TALDO1 | TP53 4736/4885CYP1A2 1111/4885ACHE 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.