SCHEMBL2348487

SCHEMBL2348487

O=C(O)c1ccc(-c2ccc(Br)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.60
BAD Q92934 1/20 0.60
TP53 P04637 1/20 0.60
TSHR P16473 1/20 0.60
HAO1 Q9UJM8 1/20 0.57
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
RXRA P19793 3/20 0.54
RXRB P28702 3/20 0.54
KDM4E B2RXH2 1/20 0.53
LMNA P02545 1/20 0.53
HSD17B10 Q99714 1/20 0.53
ALDH1A1 P00352 1/20 0.52
MAPK1 P28482 1/20 0.52
SRD5A2 P31213 1/20 0.52
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA12 O43570 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14140355 1.00 BCL2L1 (0.60) BCL2L1BADTP53TSHRHAO1
SCHEMBL71380 0.92 TSHR (0.71) TP53TSHRCES2CES1RXRA
SCHEMBL6547995 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
Hydrochloric Acid SCHEMBL532752 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL9317004 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL8767088 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL8487555 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL9318309 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL10604961 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA
SCHEMBL10614159 0.90 TSHR (0.67) TP53TSHRCES2CES1RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119708370-A ASNF-M/SiO2@CPs hybrid copolymer gel and preparation method thereof 盐城市友普环保科技有限公司 2025-03-28 CN claimed
US-20180282257-A1 Aromatic Monoester Compositions and Processes for Preparing Same EXXONMOBIL CHEMICAL PATENTS INC. 2018-10-04 US claimed
EP-1534689-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-06-01 EP claimed
US-20040242572-A1 New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-12-02 US claimed
WO-2004024702-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-03-25 WO claimed
JP-57108056-A None JP disclosed
JP-54048740-A None JP disclosed
US-12480049-B2 Compound and liquid crystal composition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2025-11-25 US disclosed
CN-119708370-A ASNF-M/SiO2@CPs hybrid copolymer gel and preparation method thereof 盐城市友普环保科技有限公司 2025-03-28 CN disclosed
EP-4368614-A1 SYNTHESIS AND APPLICATION OF PHOSPHATASE DEGRADER Hinova Pharmaceuticals Inc. (CN) 2024-05-15 EP disclosed
EP-3269789-B1 LIGHT EMITTING MATERIAL AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO LTD (JP) 2023-08-30 EP disclosed
US-20230250338-A1 COMPOUND AND LIQUID CRYSTAL COMPOSITION THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2023-08-10 US disclosed
US-5922763-A ANTICOAGULANT; CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1999-07-13 US disclosed
US-5736559-A CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS KARL THOMAE GMBH (DE) 1998-04-07 US disclosed
US-5597825-A AGGREGATION INHIBITORS DR. KARL THOMAE GMBH (DE) 1997-01-28 US disclosed
US-5580741-A INCUBATING SAMPLE SOLUTION IN CONTAINER PRECOATED WITH ANTIBODY AND PROTEIN CONJUGATE YIELDS COMPLEXES, THEN REMOVAL AND REACTION WITH CHEMILUMINESCENT REAGENTS FOR MEASUREMENT OF LIGHT INTENSITY, FOR CHLORINATED BIPHENYLS GENERAL ELECTRIC COMPANY (US) 1996-12-03 US disclosed
EP-0425930-B1 Process for the preparation of symmetrical diarylacetylenes BAYER AG (DE) 1994-09-28 EP disclosed
US-5185454-A Reacting aryl bromide with acetylene in presence of palladium catalyst and nitrogen-containing heterocyclic base BAYER AKTIENGESELLSCHAFT (DE) 1993-02-09 US disclosed
JP-S57108056-A 4'-(ALKYLOXYMETHYL)-4-CYANOBIPHENYL CHISSO CORP 1982-07-05 JP disclosed
JP-S5448740-A BIPHENYL ESTERS SEIKO EPSON CORP 1979-04-17 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242572-A1 New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture MCHR2, MCHR1, NPY1R BCL2L1 3731/4885BAD 2116/4885TP53 4875/4885
US-20180282257-A1 Aromatic Monoester Compositions and Processes for Preparing Same ADH1A, ADH1C, GK BCL2L1 3249/4885BAD 3277/4885TP53 1710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.