Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HEXA | P06865 | 2/20 | 0.44 |
| ▸ | HEXB | P07686 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14094485 | 0.80 | PDK1 (0.44) | ALDH1A1HEXAHEXBDHFRCYP3A4 | |
| SCHEMBL4691850 | 0.79 | PDE3B (0.47) | ALDH1A1MEN1CYP1A2KMT2ALMNA | |
| SCHEMBL14525876 | 0.77 | IDO1 (0.49) | ALDH1A1CYP1A2LMNASMN1; SMN2PDE3B | |
| SCHEMBL24926817 | 0.77 | TGFBR1 (0.33) | ALDH1A1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9404017 | 0.75 | KMT2A (0.38) | ALDH1A1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL17066980 | 0.74 | TDP1 (0.41) | ALDH1A1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL15730888 | 0.74 | CCNB2 (0.43) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3325880 | 0.73 | PDE3B (0.43) | ALDH1A1MEN1CYP1A2KMT2ALMNA | |
| SCHEMBL30801466 | 0.71 | CYP1A2 (0.61) | ALDH1A1MEN1CYP1A2KMT2ALMNA | |
| SCHEMBL28906692 | 0.71 | CYP1A2 (0.61) | ALDH1A1MEN1CYP1A2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2023-01-12 | — | — | US | disclosed |
| US-11034668-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034668-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | ALDH1A1 649/4885MEN1 2645/4885CYP1A2 489/4885 |
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | ALDH1A1 649/4885MEN1 2645/4885CYP1A2 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.