Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22510350 | 0.79 | GBA1 (0.40) | NPC1MAPK1L3MBTL1ALDH1A1TP53 | |
| SCHEMBL24844357 | 0.79 | TGFBR1 (0.36) | TGFBR1GABRA5GRM5DHFRMAPK14 | |
| SCHEMBL23502019 | 0.77 | ALDH1A1 (0.44) | NPC1GLAMAPK1L3MBTL1TDP1 | |
| SCHEMBL24470496 | 0.76 | KDM4E (0.45) | GRM5L3MBTL1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL24926676 | 0.76 | KDM4E (0.43) | NPC1MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL24926680 | 0.73 | KDM4E (0.48) | NPC1GLAMAPK1L3MBTL1TDP1 | |
| SCHEMBL24926786 | 0.72 | TGFBR1 (0.33) | TGFBR1NR1H4GABRA5GRM5CNR2 | |
| SCHEMBL24844401 | 0.72 | CRHR1 (0.33) | TGFBR1CRHR1NPC1MAPK1L3MBTL1 | |
| SCHEMBL23212666 | 0.70 | GABRA5 (0.33) | TGFBR1GABRA5GRM5MAPK1L3MBTL1 | |
| SCHEMBL24454554 | 0.70 | PTK2 (0.36) | TGFBR1NR1H4GABRA5GRM5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230023326-A1 | HETEROARYL-SUBSTITUTED PYRAZINE DERIVATIVES AS PESTICIDES | ELANCO ANIMAL HEALTH GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230023326-A1 | HETEROARYL-SUBSTITUTED PYRAZINE DERIVATIVES AS PESTICIDES | DDT, PRXL2A, CAT | TGFBR1 1458/4885NR1H4 3875/4885GABRA5 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.