Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992334 | 0.87 | KDM4E (0.39) | PTGDR2KDM4EALDH1A1HSD17B10ABCC9 | |
| SCHEMBL1989562 | 0.83 | PTGS2 (0.45) | GRM5MEN1KMT2A | |
| SCHEMBL1989829 | 0.83 | ABCC9 (0.43) | PTGDR2KDM4EALDH1A1HSD17B10ABCC9 | |
| SCHEMBL1993975 | 0.82 | ABCB11 (0.48) | GRM5PTGDR2PPARDPPARAPPARG | |
| SCHEMBL2351025 | 0.80 | PTGDR2 (0.40) | GRM5PTGDR2PPARDPPARAPPARG | |
| SCHEMBL1991394 | 0.79 | ABCB11 (0.38) | GRM5PTGDR2ABCC9ABCC8KCNJ11 | |
| SCHEMBL1989553 | 0.78 | HTR6 (0.51) | KDM4EALDH1A1ACLYMEN1KMT2A | |
| SCHEMBL1988525 | 0.77 | GRM5 (0.46) | GRM5KDM4EALDH1A1HSD17B10ABCC9 | |
| SCHEMBL2356023 | 0.76 | MMP2 (0.39) | PTGDR2HSD11B1 | |
| SCHEMBL14432857 | 0.76 | MMP2 (0.39) | PTGDR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008350-B2 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |